Long story short my 8800GTS paralyzed (though not quite dead) on me. So I ordered a Asus ENGTX460. That ran fine for an hour or so, but then that paralyzed on me. So I RMA'd it, and got another ENGTX460. I've had it for a couple weeks and it still survives, but it seems to have some frame rate issues.
When playing games, whenever I look at a new area, there's a big frame rate drop, or it will even pause for a bit, and then it will go back to normal. This problem didn't seem to happen on my last GTX460 (in the brief time it had) or even on my 8800GTS. I'm running the latest drivers and all that.
Here's a video with examples. At this time it's still processing so the resolution is a little low, but you might still be able to get the idea. YouTube - GTX460 Framerate stutter
OS: WIndows 7 64-bit
Motherboard: Intel DP35DP
Processor: Intel Core2 Quad Q6600
Video Card: Asus ENGTX460
RAM: 2 x 2GB PC2-5300 667MHz
Sound Card: Sound Blaster X-Fi Xtreme Gamer
Power Supply: Startech ATX2PW550PRO