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14 May 2011  
Microsoft MVP

Windows 7 Ultimate X64 SP1

Go to sounds in Control Panel and see if a sound profile is enabled. If not, choose one and try it. It will show a list of sounds for each Windows action for which the profile has a sound for and you can play it.
Tuneup may have changed a few things, but should not be irreversible. In its System Control go through that to see if there is a sounds setting.
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