You should still be able to explore the disk from my computer. (right click and select open, not the Autoplay option)
To find the cause; right click the file called autorun.ini and open that. then see what file it points to. what does that file end with (.xxx)?
Or is this the message you get when trying to open it from computer management? This should automatically use explorer.exe to open the drive but I am not sure how to change the application for opening drives themselves, running SFC /scannow from and eleveated command prompt may help.