you mean in the Bios?
Hardware thermal control can be the option for the whole unit if it gets to hot has a shut down point
cool and quiet is to operate the cpu in a fast but cool state even though it is overclocked i would doubt they will clash
if you feel that something does change while doing so just switch it back but i left all my thermal monitors and controls on i would think it was for the better
it doesnt hold my oc back at all