You would be treading on dangerous ground if you are not sure of what you are doing.
Do Not delete any empty System Directories, Folders, or files
See this post from Piriform/CCleaner: How about deleting or flagging empty directories? - CCleaner Suggestions - Piriform Community Forums
, but if you insist there is a program listed in post #7.
Do not be surprised if Directories, Folders, or files return after you use your machine for a while because some programs will recreate them for their own use.
Found this here on the forum
Deleting some files, are they save
Is it safe to delete empty folders in Windows?
Do a search for: Should you delete empty folders?