Generally the uninstall option in Programs&Features tends to clean most Creative drivers off followed by a reboot to insure nothing is still being loaded. Once that's taken care of as well as a good sweep the newer ones shouldn't run into any major headaches.
The problem most have is simply trying to rush ahead with something newer before taking the time needed to see this done. chev65 knows what I was mentioning before from running into problems with the C.Labs drivers.
For awhile Creative made a mess on their support right after Vista's release where if you went for an XP update you ended up with the Vista version instead!
Even when going through the MS update site you would see the exact same problem until finally they reorganized their support pages! Took long enough!