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20 Mar 2010  

Windows 10 Pro X64

Give LockHunter a try. It's similar to Unlocker that works well on XP.

Also, what shows from Command Prompt?

Click on Start then Run, type cmd and press Enter
cd desktop
attrib filename.ext (of the file you are having problems with)

If the S, H or R (System, Hidden, Read Only) flags are set, reset them

attrib -s -h -r filename.ext

Now try deleting the file

del filename.ext
My System SpecsSystem Spec