I have no direct experience with Samsung externals but I assume you have the following information
SAMSUNG Hard Disk Drive
Assuming you are dealing with an ordinary plain disk and not relying on special manufacturer backup software I cannot see anything special for NTFS file systems.
BUT
For a FAT32 file system you can have a partition size up to ~2TB. Windows will recognize this partition but isn't prepared to make one greater than 32GB (Why I don't know). The Samsung utility has this ability as do some other formatting utilities.
Edit: Another opinion. If you are using Windows then I think you need a specific reason to have large FAT32 partitions rather than NTFS.