According to Microsoft, if you're using Windows Backup to back up your files, you can have a system image created each time your files are backed up. The files
can be saved on a USB flash drive, CDs, DVDs, or a hard drive. The system image must be saved on a hard drive. Back up your programs, system settings, and files
This Microsoft article also says you can't save a system image on a flash drive: Where should I save my backup?
As far as other imaging software like Paragon, Macrium, EaseUS Todo, etc you might have to try each one to see if it would work. I couldn't find anything definitive.