Carol I tried https://support.skype.com/en-gb/faq/...einstall-Skype
In IE8, and it worked to get to the uninstall page instructions.
Do you mean to say you tried to delete the Skype registry keys, but could not?
Okay I follow you now. It shouldn't matter if Skype is running or not, to just delete it, but it would be best to have it not running so as not to disturb other programs.
Do a re-start of your machine when you are all done.