Best practices for managing multiple POP3 e-mail accounts ?

For years I've generated multiple (10-15) e-mail accounts on my personal domain and to manage these always configure Outlook with separate accounts mirroring each of these. Is this the generally accepted way of setting this up or would it be more wise and less work to have a default account on my domain with all the others simply set as forwarding accounts? Then in Outlook I'd only need to configure one account and all the rest would be handled through rules (which I already have a plethora of).

Unfortunately I can't at the moment wrap my head around the pros, cons, worthyness or even feasibility of this idea.

I have only 2 accounts on my Domain and prefer using Webmail [called SmarterMail provided by my Hosting service], have a Favorite/Bookmark for each. I could set an E-Mail Client for IMAP for each but if I did I would use a different Client for each one, e.g. SeaMonkey Mail for one and Windows Live Mail for the other, could also use Outlook for one but trying to stay away from Outlook.