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#11
I had this issue with an Intel SSD an tha nvidia nForce motherboard.
WHat fixed it was turning off Native Command Queueing on the ATA channel that the SSD was connected to.
Symptoms, randomyly (sometimes during boot!) program I was using would freeze, then after several seconds or longer the mouse would also freeze, harddrive light on solid.
To fix, go to the device manager, then to your ATA ports. Then on the ATA port for your root drive (There will be several ATA ports listed) On "Port 1" or "Port 2" tabs, uncheck "Enable Command Queueing".
For my SSD this actually speeded things up a little, but on a rotating drive it might slow it down a little.
Turning off NCQ on the SSD port (Was not necessary on my secondary drive) absolutely stopped the issue dead.
Enabling AHCI mode on my newest computer and using an intel G2 SSD did not require this fix (nor is it even an option int he device mamager for the AHCI driver)