I've got the previous generation model, the eeePad Transformer TF-101. It's been solid, except for the Ice Cream Sandwich rollout. I have the update, but the device will randomly reboot (only when asleep) and it won't always reboot successful, so it will just sit at the logon screen and churn until the battery dies. Also, the sound will decide to just go out and won't come back without a unit reboot.
Asus has acknowledged both issues, but we are still waiting on a fix.