Why are you asking?
This is way too complex, I'd search for a BIOS guide, and go through each setting, there is no way to just roll out a BEST configuration here. (within reason)
Your motherboard manual is a good starting point, but I can't even understand a lot of it, with the typical lack of explanations.
Guide search wise, note which BIOS is used when the PC boots up; Phoenix, Award, AMI?
Found this: Maximum PC | Ultimate BIOS Guide: Every Setting Decrypted and Explained!
If nothing else will do:
There are 3rd parties that sell customized BIOS', I have never used one, but since that is not a new PC, you might run across those, and maybe that could be what you want, I think typically $30.