Windows 7 - Mouse bugging and turning into several horizontal lines/disapearing

The only time my mouse disappears, or turns into several vertical lines when i scroll over something is when I'm in League of Legends. When i exit the game after this has happened the mouse remains as several vertical lines all the time. Ive had this computer for over a year and it just started doing this about 3 months ago and it is occurring more and more often. Used to be once a week or so, but it happened twice today. Another thing that seems to be common with this glitch is ive usually been playing League for awhile. The only thing i find that fixes this is restarting the computer, and the only thing i would think is causing this is either a virus buried deep in mouse drivers, or an error in one of the updates. I updated all my drivers and still nothing. This would be a big help if you could tell me how to fix, cause it usually means i lose in the game I'm playing.