My thanks to who ever came up with driver fix.
I can't even begin to tell you how DISSAPPOINTED I was when I found I couldn't use my scanner with a new computer because Epson was too lazy to support it
This wasn't a matter of tens of thousands of dollars in development costs, it was
only necessary to change 3 characters in an existing file. Boom ... 10 seconds ...
done. SHAME ON YOU EPSON.
Anyway, anyone in this situation can EASILY fix it. No computer genious required, just some average familarity with software installation.
Based on what I read here and figured out along the way, this is what I did to get it working on a Win-7 64 bit system.
1. Plug in scanner. Boom system does not recognize USB device, can not find or load a driver (no kidding, there isn't one).
2. Open the Devices and Printers menu and there I saw an icon at the bottom for an unknown USB device (the unrecognized Perfection 2450 scanner). Right click the icon and poke around in the menus and details and some additional sub menus for driver info and found the device was showing a PID of 1101. (Read some of the previous posts to learn what the manufacturer and PID codes are). The key point is that the device was saying USB\VID_04B8&PID_0112
The final 4 numbers are the important part, 0112.
2. Install the Perfection 2400 driver (download from EPSON). Note: this did not work at first. I found that it was necessary to empty the c:/users/"insert your user name here"/AppData/Local/Temp folder or the installer did not have enough room to write new temp files. It would just say "can't copy files" "error has occurred" "restart you computer"
Installed Fine once the temp folder was cleared out.
3. At this point the scanner still won't work because the driver is looking for USB\VID_04B8&PID_011B
Now you need to fix the driver to recognize 0112 instead of 011B. YES, thats was the only difference; B needs to be changed to 2
4. Go into c:/Program Files (x86)/Epson/escndv/es0027 There was a file called es27. This is the file to modify. About 50 lines down there are 3 lines that end with USB\VID_04B8&PID_011B Change the B at the end to 2. the line then ends
USB\VID_04B8&PID_0112 Save the new file.
note: I had to drag the file to the desktop, modify it, save it, and drag it back to the original location. My computer would not allow me save it directly.
5. Unplug the usb cable and plug it back in. Boom still not recognized. Go back into the devices and printers menu, right click the unknown USB device again, drill down in the menus and look for the UPDATE DRIVER button. Use the c:/Program Files (x86)/Epson/escndv/es0027/es27 file you just modified.
Computer recognizes the new driver and installs. The generic unknown USB icon moves to the top with a scanner icon and ID of Epson 2400.
6. The end. The EPSON scan software works, the import in Photoshop works, the Windows Fax and Scan utility works, all the features of the scanner work both the flatbed and transparency features.
This may sound hard and time consuming. Its not. If you are a computer wiz and understand what I just said, this process will take you a minute or less. If you are an average tinkerer, about 5-10 minutes before it all sinks in.
Note: the prior poster indicated the PID was 4112 for the Epson 2450. For me it was 0112. I don't think this number is fixed. It must be determined for the unit sitting on your desk by looking at the info in the "unrecognized USB device" when it shows up in your Devices and Printers list.
Didn't want to repeat what has already been said but I think I added some missing details. Hope this info helps some one else