Now a days, all devices are plug and play (PnP) because Windows will automatically detect and display them. In most cases, PnP for every device works fine. In your adverse situation, you could visit the web site of USB manufacturer to find out if they have any updated drivers versions and then install it. Make sure about the drivers compatibility issues. Don't forget to inspect physically the mouse and the wire connected to it. You can also connect wireless mouse to see if it is recognized.
Here are some further steps for uninstalling and re-installing drivers for Windows 7:
Click Start button, Right click Computer, click manage, click Device manager, double click mouse and Right click on the mouse model. Choose property and then choose the driver tab to have all options for Update driver, Uninstall, Roll back Driver etc.