I am sorry, aside from not having posted your computer specs, you almost give no information and I gotta ask... what does using hotkeys (keyboard) have to do with your mouse? Perhaps if you explain your problem a little more, I (or some one else) can give you more help?
Computer type PC/Desktop System Manufacturer/Model Number Custom Built OS Vista x64 + Windows 7 x64 (Ultimate) CPU Intel Q9650 Motherboard EVGA 780i FTW Memory 8GBs Corsair Dominator 1066Mhz Graphics Card Asus GTX660 (2GBs) + MSI 9600GT (PhysX) Sound Card Onboard Realtek HD Monitor(s) Displays Acer AL2216W Screen Resolution 1680 x 1050
Keyboard Logitech G15 Mouse Logitech G9 PSU PC Cooling 750w Silencer Case Thermaltake Spedo Advance Cooling CM 8V Hard Drives WD VelociRaptor 300GB
Samsung 750GB 32MB cache
1.5 TB Internet Speed Comcast 20Mbit Antivirus Avast Browser Firefox