I'm not sure if you're using multiple versions of Set Point, but here's a tip if you are. When installing multiple versions of Setpoint for a mouse and keyboard, you need to installed the oldest version first and then install the newer one. You would think that all versions of Setpoint would support all devices that use the software, but in order to save space Logitech hasn't done this, or atleast didn't used to. Therefore, you'll want to check to see what the version numbers of each Setpoint installation is beforehand and make sure to install the older one first.
Once you have Setpoint installed, you can program your mouse and keyboard. For more information on how to used Setpoint, check out the support pages on the logitech website. SetPoint