Okay, well I would say that you have a clue there.
Do you have S.M.A.R.T. enabled on your hard drive? It may be available in your BIOS if you are up to checking on this. It should NOT affect your drive data (in my experience, when in doubt, consult your Mobo manuals) but will report potential points of failure.
What happens with Malwarebytes? Similar IO error reports?
Also, to rapidly track down lagging head out to Microsoft's
Sysinternals Suite and at least download Process Explorer. It will reveal amazing things about what process is locking up your system...
Keep us posted...