popup's all the time

Do you have a wired or wireless keyboard? If wireless, does it have a separate receiver to the mouse? Can you try a wired keyboard with the wireless mouse to see if that makes any difference.

This may be a silly question. Is the mouse set up in the properties as left or right handed?

I have a wired keyboard.
The mouse is setup for right handed.

Oh well. It was just a thought.

I downloaded and installed "StopZilla". Did a scan and found 37 infections. Of course they wanted me to buy to remove the infections. All infections were in the registry. I did a search on the same words and even looked for the registry address for these infections. couldn't find anything. So gave up on that piece of software.
I then downloaded and installed "Spyware Doctor" from Pc Tools. It found 7 threats and 383 infections. None of which was what "StopZilla" found.Again they wanted me tol buy the sprogram to remove the bad guys. And, again, I did a search on what they purported to find and, again. came up with nothing.
So if spyware is giving me the popup problems these guys probably will not help.

Did a clean install of the OS and buildup from there. Problem solved.