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Set your screen resolution to the highest possible and make sure that is the native resolution for the monitor. That's all you can do. If things got smaller, that means you are running in a higher resolution, which is good.
deanolfc told you how to change the resolution: Things got small! :( and you said it didn't work, actually you said "Tried, can't".
Are you saying you can't change the resolution? What do you see when you click on "Change resolution" under Display?
On my Pro X64 with NVIDIA Quadro FX 3400/4400 and a Westinghouse 22" display, I see this: