Folders Dont function

When i insert USB Drive i am experiencing this the folder just load but its not opening at all, plus all the icon was gone , i have done scans for both malware and anti virus but none found.. The only solution for this is when i remove the drive and restart the pc. I also experience this when sorting items without the usb inserted. After this "problem i often get "The remote procedure call failed and did not execute."which restart is the only option.

Try a anti-malware scan with the USB plugged in using Microsoft Standalone System Sweeper Microsoft Standalone System Sweeper Beta | Microsoft Connect

Did you try the Microsoft Standalone System Sweeper? Don't ignore what advice I give you, just do it. Also, run sfc /scannow from an elevated command prompt (Run as Administrator).