Windows can't access file. May not have permission to access.

Hello,

I am attempting to access an application.exe file on my desktop. Each time that I click on it the Windows message, "Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item." pops up. I am the system administrator so this should NOT be a problem but apparently many out there are dealing with this as well. I can delete, move and even copy the file but I cannot run it. There is no option for override with password or grant permission. It just says that I cannot run it. Any help would be greatly appreciated. Also, the system I am running is Windows 7 Ultimate x64.

Thank you. I have tried and the permissions are all checked except for "special permissions." Could this be the problem? I have Star Unlocker but cannot use it for this problem because it does not even let me have the option of choosing whether or not to override it. Any other suggestions?

I already have ownership of the .exe file on the account that I'm using. I use Star Unlocker and when I try and use it here it first says that "No Locking handle found." Then it gives me options to delete, rename, or move the file. Any other suggestions?

No, it gives me the same error message. When I spot my permissions that are allowed the only box unchecked is "special permissions." Could that be the problem?

It's for a simple IRC for my website.