Ok, I give up. I've been trying to fix this one my own for two days, and I've got no clue. For some reason I suddenly cannot open or save files on my desktop. It tells me I don't have sufficient permission. My account is the admin account, I've checked the Desktop security settings to make sure I'm still listed as the owner, and I am. If I drag and drop a file from the desktop to another folder, like one of my libraries, it works fine, but if I try to run it off the desktop I get some variation of, "You do not have sufficient permission to access this file".
As I said, I checked permissions and ownership, all seems good. I also did a Restore to 4 days ago, changed nothing.