Wanchoo the same situation is happenning to me. As it happens, both buttons on my mouse work perfectly inside my browser, but not on the desktop, unless I reboot. I dont know it it's running certain programmes like virtual box or what ever that do it. What's more I cant help feeling that if the mouse were the culprit you would have had some cues in the person's question. Like she/he would have said it works nowhere.