I will want to know what those files are. If those are important system files, they should not be deleted.
Otherwise, you may have a try with Unlocker
. Edit :
Now I know that those are adobe files. What does that mean ? Files in adobe's installation directory ? Or files generated by adobe programs ?
For first option right, dont delete please.
For second option right, if a restart does not work, go for Unlocker .