Severe problem with my computer. Can't open programs.

First and foremost I would definitely follow Brink's advice regarding System Restore. But you may want to try it while in Safe Mode.

If you want to try something different then try these:

Click on Restart and hit F8 (for most computers) to enter start up selections. Click on Safe Mode with Networking and enter. (While in Safe Mode when you click on My Computer or Recycle Bin and nothing happens, it's pretty well determined that you have to do a System restore...and it can be done while in Safe Mode. See Brink's tutorial below on how to do it). Once in Safe Mode launch whatever browser you use and go to Microsoft's site and download and install Security Essentials. Run a full system scan. Malwarebytes is excellent, but this is another very good A/V and malware detector that may catch something Malwarebytes missed. Some like Security Essentials, some don't. I'm a big fan and the ONLY A/V and malware detector on my computer. It has caught things missed by other programs and I've NEVER had malware or a virus since installing. Personal opinion.

Next in line would be to download, install and run Combofix from here: ComboFix Download. A very good program for hunting down and fixing computer threats. (Personal choice)

One thing I would definitely do is download Hijackthis. It does not have to be installed. Just run the executable. HijackThis Download. After you run it it will create a log file (.txt) and put it on your desktop. Open your browser and enter http://hijackthis.de in the address bar. You can either copy and paste the entire contents of the hijackthis text file into the space provided at the bottom of the page or you can click on browse to locate the file. Click on Analyze. Hijackthis will analyze the text file and then display a detailed report on what is good, neutral or bad. If you run it and you can't interpret the results, post the .txt file here.

If nothing found then run chkdsk. Follow this tutorial and run it based on what you can and cannot get to start. Probably have to run it at startup.Make sure to check the repair option. https://www.sevenforums.com/tutorials/433-disk-check.html.

You probably have malware that has to be gotten rid of first and foremost and if it were me I would do it from Safe Mode. System Restore is still you best option. Just go back far enough when you KNOW that the system was working properly. You may have to reinstall any programs you installed after that date, but that's a small price to pay for getting your basic operating system to function properly.

These are just my opinions and things I would try based on the symptoms you posted.