Can't open programs in normal mode

Hello, I have an Acer Aspire 5532 Windows 7 64bit Home Premium and I have been recently encountering problems. My computer loads up perfectly fine but when i click on an icon the load up circle starts and then it stops loading in 2 seconds. I patiently wait but it just doesnt start and my computer freezes afterwards so i have to turn my computer off the unsafe way. I cleaned up my disk, unchecked unneccesary startup items in msconfig, checked registries for errors, defragmented my disk, use an antivirus, use malware bites, troubleshooting, ms config and none of it seems to resolve my problem. The only way i can open up programs is if I use safe mode and safe mode with networking. I will be quite awake to respond to any suggestions.

First I would try sfc /scannow. This is Windows 7 way of checking it's own System Files. Run it 3 times with a boot after each. Let us know the results.
You could also try starting a new user account.
http://www.sevenforums.com/tutorials/1538-sfc-scannow-command-system-file-checker.html

http://www.sevenforums.com/tutorials/181024-user-account-create.html

kobg,

Besides the excellent recommendations from LaybackBear,

Need following which will help us to help you:
Update your SevenForums System Specs
User CP (located on the top menu bar) |
Your Profile | Edit System Spec (left-hand column)

To gather info, use Speccy (my favorite) or SIW or System Info

In the System Manufacturer Block, enter:
Ø Manufacturer and Model OR Custom build.
Ø ADD the word laptop, desktop, netbook or tablet.
For example:
Toshiba Satellite L305D notebook.

Provide full windows version info, for example:
MS Windows 7 Ultimate SP1 64-bit

Use the “Other Info” block for Optical Reader,
Mouse, touchpad, wifi adapter, speakers, monitor, etc

Scroll down and click on SAVE CHANGES.

With Speccy, you can select with your mouse/touchpad info from the display
and paste that info into your specs.

SIW is a marvelous program, but the free version does not offer
this capability.
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With that out of the way, then:

Install CCleaner:
CCleaner - PC Optimization and Cleaning - Free Download

list of STARTUP PROGRAMS

CCleaner | Tools icon | Startup button | Windows tab |
click on Save to text file button (bottom right side) |
accept Startup.txt as file name | SAVE button

list of SCHEDULED TASKS

CCleaner | Tools icon | Startup button | Scheduled Tasks tab |
click on Save to text file button (bottom right side) |
enter Scheduled Tasks as File name | Save button

List of INSTALLED PROGRAMS

CCleaner | Tools icon | Uninstall button |
click on Save to text file button (bottom right side) |
accept install.txt as File name | Save button


UPLOAD, as an attachment, the startup.txt file
UPLOAD, as an attachment, the Scheduled Tasks.txt file
UPLOAD, as an attachment, the install.txt file.

HOW TO UPLOAD
Post a File or Screenshot in Seven Forums