I ran Office 2007 on two Acer and one ASUS netbook without any problems. Office 2007/2010 (don't know about 2013) aren't able to work with PDFs. You can create them from Word docs if you have Adobe Acrobat (not the reader) or a virtual printer installed. I never had to work with any really large files so I can't advise on that.
If you are planning on doing any serious work, you would be better off getting a notebook or small laptop. You can have more RAM, a faster processor, more storage, a better keyboard (instead of one designed for a six year old with small hands), and an easier to read display for not a whole lot more than the netbook. The only advantage of a netbook is it is more portable. They aren't suited for much more than checking emails and web surfing (hence the name netbook)