Artifacts can be a sign of a unstable OC.
You are still seeing them even at default clocks though, correct?
And when you say Artifacts, exactly what are you seeing? A screenie would be helpful if possible.
May also be a conflict betwern the game itself and a enabled feature such as AA.
As far as your
drivers go, I personally have found 260.71 to be quite stable, and still using them myself. I don't think they would be causing the issue TBH.
It wouldn't hurt to try the newest
drivers to see if they help & certainly worth a try.
Personally I found 275.33
drivers to be a bit buggy, but not everyone will. Theres actually a newer set out now too to try.
Beyond that, the only thing I can suggest is to test the card and see if any artifacts show up during a full load test.
Something like Evgas OC Scanner for example, although others may have a better suggestion.
If the stress test comes out good, and artifact free, I would guess it has something to do with that particular game.