Can you run 4 displays on a single graphics card?

Is there a way to run 4 displays on a single graphics card?

I know there are some graphics cards with 4 mini DisplayPort and you can get adapters for DVI and HDMI, but most graphics cards have two dual-link DVI outputs

I know you can run 1920x1200 on a single-link DVI and 2560x1600 on a dual-link DVI, but can you run two individual monitors say 1680x1050 each from a single dual-link DVI output via a splitter?

The video cards at work have a single DMS-59 output which can split into two dual-link DVI outputs.

It seems there is no video card with two DMS-59 outputs, so four Mini DisplayPort outputs is needed like this card here: AMD FirePro 2460 Multi-View: four Mini DisplayPort sockets, 13W, no frills -- Engadget

It would probably be cheaper to get two PCI video cards.