Hello, I have a completely different PC and it's having the exact same problem. The USB drops at odd intervals, and after a couple of seconds comes back, with the appropriate sounds. The lights on the mouse go out, and when it comes back, they're back on and all's well again. Unfortunately, there's no real rhyme or reason that I can discern. It has happened when I open new web pages, new apps. Very weird, I've never had this happen before. It started after I installed windows 7, maybe around the August-September 2011 timeframe. I have one powered USB hub, which I've disconnected and it still happened several times afterwards. I also have a fingerprint reader, and a UPS connected via USB in addition to my old Logitech Razor. My wife has an HP laptop, and it does the same thing at odd intervals. Admittedly, she has an unpowered USB splicer which seems to cause it to happen more often. But other than that, it happens regardless. I've updated drivers as much as possible. I have the one un-installable Microsoft Windows update file (15KB) that utterly refuses to install (others have that problem as well and is probably unrelated) but other than that one, all patches are in. So from what I can tell from various posts on this problem, it seems to be a cross platform issue, with Win 7 being the only common denominator I can find. Any new ideas?