I run Windows 7 on two of machines. One runs flawlessly. The other ran flawlessly for about a month or two, and then I started getting a rather odd problem. The OS fails to recognize my (mostly) left mouse clicks for random periods of time, say 5 seconds to like 60 seconds. It'll work, then it'll stop, then it'll work... etc. Obviously this is extremely frustrating. Thinking it's the mouse, I tried another mouse - same problem.
Both mice are USB, but it does not seem to be an issue with the USB ports as my keyboard and other USB peripherals work fine.
Running the C2D Extreme Quad core from a couple of years ago, X38 chipset board, 4870x2.
I'm baffled on this one, hopefully someone out there has an idea. Oh, I formatted and reinstalled the first time this problem came up, and it started again within a few hours of the reinstall. All I've got installed besides my drivers
ATI Catalyst Control Panel