Windows 7: Corrupt drive?

I'm using SyncBackPro to do backups to my 500 & 320gb drives, but every time I try to backup my backup (320 to 500gb drive) for offsite storage seemingly randomly it will stop on one file (seemingly a random one) and will just be 'copying' it until I stop it.

But, stopping it causes the program to hang, which I force close. Then I try ejecting the drives but cannot do so as it's still in use. I close Chrome and uTorrent etc and cannot shut down as Explorer has hanged - but these apps have been closed down.



Restarting the pc (win 7) I find all my utorrent settings gone/defaulted, same with Syncback, and same with Chrome - in fact even through I've closed Chrome 20 mins before turning the comp off by pulling the power it's reporting a corrupt profile and defaults to a wiped/default installtion.

Surely a copying error shouldnt do this, nor should exiting apps and turning off the pc?

Any ideas? I've scanned the drives and no errors are found - I'd look at my SyncBakc Pro logs but I don't get one as it crashes.

Edit: I'm using TrueCrypt on all drives, but that shouldn't be a problem should it? When Syncback hangs, TrueCrypt does so, too, when I try to dismount the drives.