Unable to open F: drive, "Application Not Found" error

Recently, I've been unable to access my F: drive. When I double click on the drive I get en error that says "Application Not Found". I can, however right click on the drive and open it that way, it's just extremely annoying. It doesn't matter what device is set as the F: drive, be it a UBS drive, a virtual drive, or a CD/DVD drive, it gives me the same error. At first I thought maybe there was something wrong with my USB drive, but if I use the same USB drive as E:, G:, H: etc. it works perfectly fine. The problem seems to lie specifically with F: drive itself. I've run all my virus scans (Norton and Malwarebytes) as well as PC Tools Registry Mechanic and found nothing. I even restored my system to about a week ago with no results. Any help would be appreciated.

I did come across something interesting though. I previously installed Flight Simulator X using either MagicISO or PowerISO as a virtual drive. At that time, I believe that I installed it using the F: drive as the virtual drive. Im going to attach a couple pics, one is of a USB drive as any random drive, and the other is a UBS drive as the F: drive. When I right click, my options are different. With the F: drive, the default action is "install or run a program from your media", as well as install direct X and install flight simulator. Could the fact that I installed flight simulator on the F: drive be messing it up? keep in mind all of my virtual drives are unmounted. How do I change the default action on the F: drive back to "open" like the other drives?

i am able to boot from boot-able disc but within OS windows 7 it is unable to read any kind of CD or DVD please suggest any solution if any registry value need to be change please suggest