All the ASUS recommended drivers installed? On my Acer Aspire laptop a lot of those custom keys didn't work with the basic default Windows 7 drivers. I had to install the Acer drivers. On my Acer, the media keys were actually connected as part of the touch pad and didn't work until I installed the correct Acer supplied Synaptics driver. The keys I'm referring to were play/pause, next, back, and stop. It really had me scratching my head trying to get them to work, because any desktop keyboard I ever owned with those keys on it, worked right away in Windows, without having to install any special drivers or software.