I recently rebuilt my domain controller, and then had to create a new user profile on my Window's 7 Ultimate x64 computer when I enrolled into the rebuilt domain. Since then, I cannot get a connection when plugging my Windows 6.1 phone into the USB cable to use Windows Mobile Device Center.
I was able to enroll my phone into the rebuilt domain and it does sync email, contacts, and calendar off Wi-Fi to the Exchange server without any problems. That Wi-Fi sync won't sync notes, one-note files, data files. or music. Those require a USB connection.
I tried removing the phone and mobile device center, and then reinstall them, but it makes no difference.