I am new to this forum but have seen this issue before with answers that do not solve the problem. On a new start or reboot the mouse works on the desktop icons for a few minutes and then stops working; ie, it doesn't highlight or open any desktop icons.
I have tried a different mouse and the issue remains, so it is a software or system problem. I have windows 7 64 bit on an HP desktop with loads of hard drive and memory. Any suggestions?