What you want to do is see what's working well for other people playing the games you want to play. Being your own test bed can get expensive real fast. Reading owner reviews and even looking at specs posted on Youtube work for that. Some vid cards really have trouble with some games. Unfortunately, sometimes people have the card before the game comes out. Game designers can't test every possible combo. That's why I prefer mainstream Intel/nVidia - more likely they were tested during game design testing. But many combos not tested still work well, and finding them isn't hard to do.
Some MB/vid card combos don't work well together. What's in my specs has worked well with everything I've thrown at it, but there are many setups that work.
Mine is already pretty old, and the only thing I've noticed wrong in playing many high-demand games was the spider webs blocking some passages in Skyrim were invisible. So when I got stopped I just started hacking, then they showed up.
I wouldn't get any MB/vid combo that I didn't see working well for the games I play.
Of course "issues" can still rear up when new games are released, usually solved by new drivers
Best not to get into that driver
issue in the first place. I'm still using the drivers I installed 2 1/2 years ago when I built this system.