You have ruled out mouse drivers
, and I assume you are reasonably sure there are no conflicting mouse and/or keyboard drivers (Software installed and showing in the Programs folder).
I'm not sure what "formatted Windows" means. Did you reinstall the OS and all your programs?
But the next likely suspect is your graphics driver
. Have you made any recent changes there?
You can test this by going into Safe Mode. Does the mouse behave properly there?
If it does you can further test this by uninstalling CCC and the graphics driver, restart and let Windows install it's own generic driver, restart to complete the configuration, then see if the mouse works properly without the AMD driver.