Stop dvd drive from automatically opening

edit: Sorry, I missed this part in your post. I don't know anything about Xplorer2.
It seems to mainly happen with my 3rd-party file manager called 'Xplorer2', and not Windows ExplorerThis is odd behavior. Does it always go to the DVD? And it has to choose from the alt menu to eject.

I suggest a quick malware scan with Malwarebytes.

Please go to the Malwarebytes Anti-Malware Download
Save to the Desktop
Double-click the downloaded MBAM file to run it.

When the installation begins, follow the prompts in the setup process.
Do not make any changes to default settings and when the program has finished installing, make sure only the following options are checked:
>Update Malwarebytes’ Anti-Malware
>Launch Malwarebytes’ Anti-Malware

Uncheck: Enable free trial of Malwarebytes Anti-Malware PRO
Click on the Finish button.

If an update is found, the program automatically updates itself.
At the program console, on the Scanner tab, and select: Perform Quick Scan

Next, click on the Scan button.

When the Malwarebytes scan is completed, click on: Show Results
When presented with a screen showing the malware detected, make sure everything is Checked, and click on: Remove Selected

When removal is completed, a report opens in Notepad.

Please copy/paste the entire contents of the MBAM report in your reply.

Note: If MBAM encounters a file that is difficult to remove, you are asked to reboot the computer so MBAM can proceed with the disinfection process. If asked to restart the computer, please do so immediately. Failure to reboot normally (not into safe mode) prevents MBAM from removing all the malware.

Does the mouse cursor always go to the DVD and always seclect eject.

Good news on Malwarebytes.
I took a quick look at xplorer2 and if the action is always the same (DVD/eject) then it's most likely caused by a script or other user defined action.

I didn't find anything specific to your post.

Take a look at these
FAQs: xplorer² Fact Sheet: improved file handling
Online Manual: xplorer² online help: Introduction to Explorer replacement

Good luck, wish I could have been more help.

Bill