I've just finished upgrading from XP to Windows 7 via Vista business. I upgraded my BB Desktop Manager to version 220.127.116.11 (Aug 21, 2009). Blackberry Bold & Windows 7 are working and playing well with each other now, but I did uninstall & reinstall DTM using RevoUninstaller to be sure the registry keys were cleaned out.
Because I did not do a clean install of Windows 7, I ended up with pretty severe permissions issues, but after spending alot of time manually giving myself rights to my files and folders things ran well. I originally forgot to configure synchronization in DTM and couldn't get synchronization between Outlook & Blackberry to work, but that was my own fault for not reading the instructions again.
FYI, I've attached the version information of all the components installed on my PC.