I have a Razer Copperhead USB Mouse.
Specs of my desktop can be found here: TechComet: My Gadgets
Basically, I put my desktop to sleep (using S3-STR) and when I wake it up my moues does not respond for about 15-30 s after which it works fine. I am running Windows 7.
I have no other problems with my system, my keyboard responds fine and I have all necessary drivers
I have no idea why this is happening and the fact that my computer resumes from sleep in 2 seconds is great, but not when I have to wait another 30 for the mouse to work!