I have a sysprep'd Latitude E6420 image and will attempt to use that against a Lattitude D630. Different laptop. Will let you know. I will then use the same image on a Desktop machine.
Btw it's Win XP.
Update: Device Manager showed missing drivers
SM Bus Controller
video Controll (VGA Compatible)
From above errors, these are built in devices. A change in mobo will definately effect the image.
As previously mentioned, sysprep image will be make and model specific. Hardware independent would be Machine A, Machine B, Machine C etc, but all are the same make and model.