You'd only need SysPrep
if you were changing to different mobo or other major hardware changes. Just a HD itself is usually not a problem when reimaging to it from either Windows 7 backup imaging or one of the other more favored apps like Macrium which is probably the favorite around here.
For many the fact that you can change the partitioning layout when using Macrium is enough reason to use it, since Windows 7 backup imaging requires you to keep the same offsets.
How it's run is in the Manual at the Download link Gary provided above.