xt2k,
That is what I did on my main computer that has a billion apps (give or take a billion). The Vista Home Premium upgrade worked great, although it took hours to finish. Most devices worked after the upgrade, and I only had to sort out a few
driver/app issues. The best part is that most of my apps got brought along without pain and sorrow. Now, I am looking forward to upgrading to 7 in a few weeks (or less).
On my other 3 computers, I will do the "easy transfer" and clean install thing, which I think may not be as "easy" as it sounds.