New
#21
All my HDDs don't exceed 2TB( MBR format by choice) so my comment is an opinion.
My understanding is that your OS drive can be MBR and large (> 2TB) data drives formatted GPT should be fully compatible. If you convert your 4 TB drive to MBR then I think you will only see 2TB. So > 2TB for data drives then GPT is the way.
Now ask the more unknown question concerning Macrium system imaging. Can you create a macrium (free) system image on a GPT data drive and restore to the MBR OS drive. I think you can ????