Clean install is the way to go. In-place Upgrade is a corruption path from the worst OS into the best OS ever.
If there is ever a time to clean install, this is it.
Back up your files and gather your program installers/disks.
Boot from the DVD, keep ethernet plugged and "connect to the internet during install" to get latest drivers
/Updates into installer during install, select Custom install, then use Drive tools to delete all, create new partition(s) as you wish, and format before installing to first partition.
After install, new drivers will arrive in Windows Updates. Check Device Manager for any missing drivers which can be found on the Support Downloads page for your computer model along with favorite apps, or on your drivers/apps CD if you have one.