Sadly, no. Ever since XP Media Center 2005. The only thing you can do is use MCE to tune to the OnDemand channel and then use the remote control from your cable providor to navigate from there.
I was hoping to see some sort of compatibility in Windows 7 Media Center, but no such luck.
One piece of good news is that CableCard V 2 should be out shortly, and it will support Tru2Way, so with a Digital Cable Tuner, you can then get your On Demand and Pay per View.
But untill then . . . .
Hope this helps